Antibody response to SARS-CoV-2 WT and Omicron BA.4/5 of inactivated COVID-19 vaccine in patients with lung cancer after second and booster immunization.

COVID-19 inactivated vaccine-induced humoral responses in patients with lung cancer (LCs) to SARS-CoV-2 wild-type (WT) strain and variants BA.4/5 after the primary 2-dose and booster vaccination remained unknown. We conducted a cross-sectional study in 260 LCs, 140 healthy controls (HC) and additional 40 LCs with serial samples by detecting total antibodies, IgG anti-RBD and neutralizing antibodies (NAb) toward WT and BA.4/5. SARS-CoV-2-specific antibody responses were augmented by the booster dose of inactivated vaccines in LCs, whereas they were lower than that in HCs. Enhanced humoral responses waned over time after triple injection, notably in NAb against WT and BA.4/5. The NAb against BA.4/5 was much lower than WT. Age ≥ 65 was risk factor for immunization of NAb to WT. Undergoing treatment resulted in a lower antibody response than those without and radiotherapy was a also risk factor for seroconversion of NAb to WT. Lower lymphocyte counts contributed to a lower titer of IgG anti-RBD and NAb against BA.4/5 in LCs than HCs. Specifically, total B cells, CD4+T cells and CD8+T counts were correlated with the humoral response. These results should be taken into consideration for the elderly patients under treatment.

Family functioning and mental health among secondary vocational students during the COVID-19 epidemic: A moderated mediation model.

With the global outbreak of COVID-19, people are facing great physical and mental stress, and mental health problems are becoming increasingly prominent. Some theories emphasize the role of family in people's mental health, but the association between family functioning and mental health and the mediating and moderating mechanisms underlying this relation have not been extensively researched. This study examined whether loneliness mediates the relation between family functioning and mental health and, if so, whether this mediating effect is moderated by hope. A total of 5783 Chinese secondary vocational students completed measures of family adaptability and cohesion, loneliness, mental health, and hope. The results indicated that family functioning had a significant and positive predictive effect on the mental health of the students and that this relationship was partially mediated by loneliness. Further, hope moderated the relationship between family functioning and loneliness. Specifically, the relationship between family functioning and loneliness was significant for students with both high and low levels of hope. The current study contributes to a better understanding of the influence of family functioning on mental health, especially during trying times such as the COVID-19 epidemic.

Comparative analysis of SARS-CoV-2 receptor ACE2 expression in multiple solid tumors and matched non-diseased tissues.

The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a global public health emergency. SARS-CoV-2 employs the host cell receptor ACE2 for cellular entry. Nonetheless, the differences in ACE2 expression pattern in lung versus other normal and solid tumor tissues remain incompletely characterized. Here, we analyze a large data set comprising ACE2 mRNA expression for 7592 tissue samples across 22 types of primary solid tumor and 4461 samples across matched 18 non-diseased tissues. Our results unravel eight normal tissues and 10 primary solid tumors, which might be at high risk of SARS-CoV-2 infection. These findings may provide additional insight into the prevention and treatment of SARS-CoV-2 infection, in particular for patients with these 10 vulnerable cancer types.